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The synthesis of 7-deaza-7-iodo-2′-deoxyadenosine. (i) NaH, CH3CN, then 1-chloro-2-deoxy-3,5-di-O-p-toluoyl-α-d-erythro-pentofuranose, room temperature, 71% (20); (ii) N-iodosuccinimide, DMF, room temperature, 3 days, 90%; (iii) N-iodosuccinimide, DMF, room temperature, 71%; (iv) NaH, CH3CN, then 1-chloro-2-deoxy-3,5-di-O-p-toluoyl-α-d-erythro-pentofuranose room temperature, 71%; (v) NH3/MeOH, 70°C, 4 days, 88%.
