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The synthesis of protected C7-amino-modified 7-deaza-2′-deoxyadenosines from 5-iodo-2′-deoxyadenosine. (i) N-propynyltrifluoracetamide, Pd(PPh3)4, CuI, Et3N, DMF, 60% yield; (ii) NiCl2/NaBH4, MeOH, –78°C, 58% yield; (iii) PtO2, H2, MeOH, 98%.
