Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A summary of spontaneous transformation studies with mouse BMMSCs
| Transformation after | Type of sarcoma | Associated genetic event(s) | Reference |
|---|---|---|---|
| Long term culture |
Osteosarcoma |
Aneuploidy + CDKN2A/p16 loss |
[4] |
| Abnormal karyotype |
[6] |
||
| Fibrosarcoma |
p53 mutations |
[24] |
|
| Chromosomal instability + TERT and c-myc expression |
[16] |
||
| Undiff. soft tissue sarcomas |
Aneuploidy + chromosomal translocations |
[17] |
|
| Short term culture | Soft tissue sarcomas | Aneuploidy | [18] |
