Table 4.

A summary of sarcoma types from different transformation studies in mice

Sarcoma type	Cell of origin	Targeted genes	Reference
Osteosarcoma	Mouse BMMSCs	-	[4]
		-	[6]
		C-myc overexpression and Ink4a/Arf knockout	[16]
	Mouse osteoblast precursors	Tp53, Rb double knockout	[56]
	Mouse osteoblasts	Tp53knockout	[57]
		Tp53 and Rb double knockout [57]
		Tp53 knockout	[17]
Leiomyosarcomas	Mouse AMSCs	Tp53 knockout	[14]
		Tp53 knockout	[24]
		Tp53 and Rb double knockout [8]
	Mouse smooth muscle lineage cells	Pten knockout	[30]
“Fibrosarcoma”	Mouse BMMSCs	-	[58]
	Aged mouse BMMSCs	-	[25]
	Mouse AMSCs	P21 knockout, Tp53 heterozygous knockout	[24]
Pleomorphic rhabdomyosarcoma	Mouse skeletal muscle cells	K-ras overexpression and Tp53 knockout	[32]
		K- ras overexpression and Tp53 heterozygous knockout [32]