Amph causes head immobilization in a LGC-55-dependent manner.
A, Wt (A), lgc-55 (B), and dat-1;lgc-55 (C) animals did not show head immobilization when tested in control plates (n = 18, 20, and 26, respectively). A, 30 mm of tyramine or Amph induced head immobilization in 100% wt animals (n = 20 and 38, respectively) after 5 min treatment. B, 30 mm of tyramine or Amph induced head immobilization in 0% (n = 20) and 25% lgc-55 KO (n = 35) animals, respectively. C, 30 mm of tyramine or Amph induced head immobilization in 0% (n = 28) and 15% dat-1;lgc-55 KO (n = 33) animals, respectively.