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Binding affinities of Ca2+ for wild-type or mutant derCD23 studied by ITC
Mutants E249A, D258A, and D270A showed no measurable Ca2+ binding.
| Ca2+-binding site | Construct | Binding affinity (KD) |
|---|---|---|
| Wild type derCD23 | 1.5 mm | |
| Principal | E249A | Not measurable |
| Principal | D270A | Not measurable |
| Auxiliary | S252A | 1.5 mm |
| Auxiliary | D258A | Not measurable |
| N269A | 0.73 mm | |
| N269D | 1.5 mm |
