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Model for RALA dependent FOXO4 regulation. Upon ROS signaling, RALA is activated by RLF on JIP1. Subsequently, the binding and activation of both MLK3 and MKK4 on JIP1 is mediated by RALA, which ultimately results in activation of JNK. Finally, activated JNK can phosphorylate and activate FOXO4. For further details see text.
