FIGURE 9.

Reactivity profiles of α₁PDX exosite variants with furin loop variants. Reactivity of α₁PDX-YE exosite variant with furin variable loop mutants and with furin(298–300) loop chimeras (left-hand panels). Reactivity of α₁PDX-serpin B8 P6–P5′-YE dual chimera with the furin variable loop mutants and 298–300 loop chimeras (right-hand panels). k_a values are from Tables 3 and 5. Reactivity profiles of the furin loop variants with α₁PDX variants are expressed relative to wild-type furin reactivities.