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Schematic of TWEAK-Fn14 signaling via SGEF and RhoG to drive glioma migration/invasion. TWEAK ligand binding to the Fn14 receptor results in the activation of RhoG by the SGEF guanine nucleotide exchange factor. SGEF-RhoG signaling results in the activation of Rac1 via additional guanine nucleotide exchange, promoting cytoskeletal reorganization and glioma cell migration and invasion.
