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. 2013 Jun 10;288(30):21955–21971. doi: 10.1074/jbc.M112.444224

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Juglone attenuates MPTP-induced Pin1 expression in mouse SN. Mice were treated with juglone (3 mg/kg) 24 h before MPTP treatment. Twenty-four hours after the last dose of MPTP, mice were sacrificed, and SN sections were immunolabeled with different antibodies. A, DAB immunostaining of Pin1 in SN is shown. The inset in MPTP group shows a single enlarged Pin1-positive cell. B, mice SN tissue sections were immunolabeled for TH (marker of dopaminergic neurons) and Pin1. Insets in Merge panel of each group show higher magnified double-labeled pictures of TH and Pin1.