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. 2013 Jun 10;288(30):21955–21971. doi: 10.1074/jbc.M112.444224

FIGURE 9.

FIGURE 9.

Juglone improves motor function and loss of neurotransmitters in MPTP-treated mice. Mice received juglone (3 mg/kg) intraperitoneally 1 day before MPTP treatment, and treatment was continued for another 7 days. Five days after MPTP treatment mice were tested for motor functions. A, shown is the moving track of mice using Versaplot software. B, shown is horizontal activity. C, shown is vertical activity. D, shown is total distance traveled (cm). E, shown is total movement time (seconds). F, shown is the number of rearing activities. G, shown is time spent on rotarod. Seven days after the last dose of MPTP treatment mice were sacrificed and dopamine (H), DOPAC (I), and HVA (J) were measured from striatum by HPLC as mentioned under “Experimental Procedures.” Results are the mean ± S.E. of 10 mice per group. M, MPTP. ***p < 0.001 versus control; **, p < 0.01 versus control; *, p < 0.05 versus MPTP; #, p < 0.01 versus MPTP.