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A and B, PINK1−/− MEFs co-expressing C431S Parkin mutant and various pathogenic (A) or autophosphorylation-relevant (B) PINK1 mutants were subjected to immunoblotting using an anti-Parkin antibody for detection of ubiquitin-oxyester formation (upper panel) or an anti-PINK1 antibody to confirm expression of the PINK1 mutants (lower panel). The red asterisks indicate the ubiquitin-oxyester band. FL, full-length PINK1; Δ1 and Δ2, the amino-terminal processed forms as reported in Ref. 6.
