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. 1977 Nov;60(5):1135–1140. doi: 10.1172/JCI108865

Plasma Calcitonin in Normal Man

DIFFERENCES BETWEEN MEN AND WOMEN

Hunter Heath III 1,2, Glen W Sizemore 1,2
PMCID: PMC372466  PMID: 908756

Abstract

We measured plasma calcitonin concentrations in healthy volunteers (20 men, ages 23-45 yr, mean, 30 yr; 25 women, ages 21-46 yr, mean, 30 yr) with a radioimmunoassay capable of detecting 5 pg of calcitonin/500 μl incubation volume, or 25 pg/ml of unextracted plasma. All subjects had 4-h calcium infusion (15 mg Ca/kg), and 24 subjects had intravenous pentagastrin injection (0.5 μg/kg) on separate days. Men had higher basal plasma immunoreactive calcitonin concentrations than women (P < 0.001): mean, 49 pg/ml (range, <25-73) and 31 pg/ml (range, <25-51), respectively. 18 of the 20 men (90%) responded to induced hypercalcemia with increases in plasma immunoreactive calcitonin; only 14 of the 25 women (56%) responded. In men, the mean increase of plasma immunoreactive calcitonin±SE was 58±9 pg/ml, but for women was only 25±6 pg/ml. 8 of 10 men (80%) responded to pentagastrin with an increase of plasma immunoreactive calcitonin >30 pg/ml, compared with such a response in only 1 of 14 women (7%). These differences of plasma immunoreactive calcitonin responses between the sexes were statistically significant (calcium infusion, P < 0.02; pentagastrin, P < 0.001). The physiologic importance of these observations is unknown, but we speculate that a lifelong, relative deficiency of calcitonin in some women could play a role in age- and sex-related bone loss, particularly during the estrogen-deficient postmenopausal years.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnaud C. D., Tsao H. S., Littledike T. Radioimmunoassay of human parathyroid hormone in serum. J Clin Invest. 1971 Jan;50(1):21–34. doi: 10.1172/JCI106476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Boelkins J. N., Kenny A. D. Plasma calcitonin levels in Japanese quail. Endocrinology. 1973 Jun;92(6):1754–1760. doi: 10.1210/endo-92-6-1754. [DOI] [PubMed] [Google Scholar]
  3. Deftos L. J., Bury A. E., Habener J. F., Singer F. R., Potts J. T., Jr Immunoassay for human calcitonin. II. Clinical studies. Metabolism. 1971 Dec;20(12):1129–1137. doi: 10.1016/0026-0495(71)90038-2. [DOI] [PubMed] [Google Scholar]
  4. Deftos L. J., Habener J. F., Mayer G. P., Bury A. E., Potts J. T., Jr Radioimmunoassay for bovine calcitonin. J Lab Clin Med. 1972 Mar;79(3):480–490. [PubMed] [Google Scholar]
  5. Habener J. F., Singer F. R., Deftos L. J., Potts J. T., Jr Immunological stability of calcitonin in plasma. Endocrinology. 1972 Apr;90(4):952–960. doi: 10.1210/endo-90-4-952. [DOI] [PubMed] [Google Scholar]
  6. Heynen G., Franchimont P. Human calcitonin radioimmunoassay in normal and pathological conditions. Eur J Clin Invest. 1974 Jun;4(3):213–222. doi: 10.1111/j.1365-2362.1974.tb00395.x. [DOI] [PubMed] [Google Scholar]
  7. Parthemore J. G., Deftos L. J., Bronzert D. The regulation of calcitonin in normal human plasma as assessed by immunoprecipitation and immunoextraction. J Clin Invest. 1975 Oct;56(4):835–841. doi: 10.1172/JCI108162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Riggs B. L., Ryan R. J., Wahner H. W., Jiang N. S., Mattox V. R. Serum concentrations of estrogen, testosterone, and gonadotropins in osteoporotic and nonosteoporotic postmenopausal women. J Clin Endocrinol Metab. 1973 Jun;36(6):1097–1099. doi: 10.1210/jcem-36-6-1097. [DOI] [PubMed] [Google Scholar]
  9. Samaan N. A., Anderson G. D., Adam-Mayne M. E. Immunoreactive calcitonin in the mother, neonate, child and adult. Am J Obstet Gynecol. 1975 Mar 1;121(5):622–625. doi: 10.1016/0002-9378(75)90462-7. [DOI] [PubMed] [Google Scholar]
  10. Sherwood L. M. Relative importance of parathyroid hormone and thyrocalcitonin in calcium homeostasis. N Engl J Med. 1968 Mar 21;278(12):663–670. doi: 10.1056/NEJM196803212781206. [DOI] [PubMed] [Google Scholar]
  11. Silva O. L., Snider R. H., Becker K. L. Radioimmunoassay of calcitonin in human plasma. Clin Chem. 1974 Mar;20(3):337–339. [PubMed] [Google Scholar]
  12. Sizemore G. W., Hpeath H., 3rd, Larson J. M. Immunochemical heterogeneity of calcitonin in plasma of patients with medullary thryoid carcinoma. J Clin Invest. 1975 May;55(5):1111–1118. doi: 10.1172/JCI108012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Walton J., Dominquez M., Bartter F. C. Effects of calcium infusions in patients with postmenopausal osteoporosis. Metabolism. 1975 Jul;24(7):849–854. doi: 10.1016/0026-0495(75)90131-6. [DOI] [PubMed] [Google Scholar]
  14. Watts E. G., Copp D. H., Deftos L. J. Changes in plasma calcitonin and calcium during the migration of salmon. Endocrinology. 1975 Jan;96(1):214–218. doi: 10.1210/endo-96-1-214. [DOI] [PubMed] [Google Scholar]

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