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. 2013 Jun 10;288(30):22174–22183. doi: 10.1074/jbc.M113.463620

FIGURE 1.

FIGURE 1.

Ablation of Fgfr1 in NCCs cells leads to cleft palate. A and B, whole mount lacZ staining showed distribution of Wnt1Cre expressing NCCs in the head of embryonic (E) day 10.5 embryos bearing the ROSA26lacZ reporter and Wnt1Cre alleles. B, insets in coronal sections of E10.5 embryos bearing the ROSA26 reporter, Wnt1Cre, and the indicated Fgfr1 alleles were LacZ-stained and eosin-counterstained. C, mouse heads were collected at E14.5 or postnatal (P) day 0 for frontal facial morphology analyses. 1P, primary palate; 2P, secondary palate; L, lip; Man, mandibular process; Max, maxillary process; MT, mesencephalic tegmentum; FP, frontonasal prominence; Ctrl, control; cKO, Fgfr1 conditional knock-out; WT, Fgfr1 wild type.