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Delayed cellular proliferation in Fgfr1cKO palate shelves. BrdU incorporation assays demonstrate that Fgfr1cKO palate shelves had compromised proliferation at the E12.5–13.5 (A and B) stages and enhanced proliferation at E14.5 (C) stage. Bottom panels, numbers of labeled cells were scored from three independent samples and expressed as mean ± S.D. *, p < 0.05; dashed lines indicate the areas where the proliferative cells were counted; Epi, epithelium; Mes, mesenchyme.
