Table 2.
Summary of ROC analysis for three-gene-mean
| |
Primary cohort |
Secondary cohort |
||
|---|---|---|---|---|
| 4 weeks | 8 weeks | 4 weeks | 8 weeks | |
| AUC |
0.94 |
0.87 |
0.77 |
0.91 |
| Sensitivity (%) three-gene-mean threshold* |
|
|
|
|
| 0.1 |
100 |
100 |
100 |
100 |
| 0.5 |
100 |
100 |
100 |
100 |
| 0.57 |
100 |
100 |
75 |
100 |
| Specificity (%) three-gene-mean threshold* |
|
|
|
|
| 0.1 |
56 |
50 |
33 |
27 |
| 0.5 |
69 |
63 |
42 |
36 |
| 0.57 | 81 | 75 | 42 | 45 |
* For the baseline three-gene-mean thresholds, the cutoff of 0.5 is suggested by the two peaks in Figure 1, the cutoff of 0.1 is derived from the mean + 2SD of the healthy distribution, and the cutoff of 0.57 maximizes the sum of sensitivity and specificity of the three-gene-mean in the primary cohort at 8 weeks.