Figure 6. Optical contrast between negative and positive margins, stratified by mammographic breast density.

A–B) eCDFs of all measured sites from negative and positive, neoadjuvant-naïve margins, separated by radiographic breast density. The P-values indicated correspond to modified Kolmogorov-Smirnov tests between: 1) negative versus positive margins in low density patients and 2) negative versus positive margins in high density patients. C) Difference eCDFs calculated between the positive and negative margin eCDFs of all measured sites for both low and high density breasts. Negative values indicate the negative margin distribution has higher values of the optical variable.