Figure 5.
3H all-trans-retinoic acid (atRA) synthesis by isolated choroids cultured in vitro for 2 hrs. A. Choroidal atRA synthesis was reduced in treated eyes of chicks developing form deprivation myopia (diffuser) and increased in treated eyes of chicks recovering from form deprivation myopia (diffuser removed) as compared with contralateral controls. B. Choroidal atRA synthesis was reduced in treated eyes of chicks compensating for negative lens-induced hyperopia(negative lens) as compared with contralateral controls. C. Choroidal atRA synthesis was increased in treated eyes of chicks compensating for positive lens-induced myopia (positive lens) as compared with contralateral controls. From: Mertz JR, Wallman J. Choroidal retinoic acid synthesis: a possible mediator between refractive error and compensatory eye growth. Exp Eye Res, 70(4): p. 519–527 2000. Reproduced with permission © Elsevier