Table 4. Age and gender-adjusted associations of glutathione peroxidase activity with cardiovascular risk factors (web only).
| Risk Factors | Unit Change | Age and gender-adjusted OR (95% CI)* | P |
| Age | Per 5 y | 0.85 (0.77–0.94) | 0.0008 |
| Gender | Male vs. female | 1.01 (0.80–1.27) | 0.91 |
| Hypertension | HT vs. NT | 0.71 (0.56–0.90) | 0.005 |
| Diabetes | Absent vs. present | 1.10 (0.69–1.74) | 0.67 |
| Cigarette smoking | Current vs.never/past | 0.93 (0.63–1.38) | 0.75 |
| Body Mass Index | Per 5 kg/m2 | 0.77 (0.67–0.89) | 0.0004 |
| Total cholesterol | Per 0.8 mmol/l | 0.98 (0.90–1.06) | 0.64 |
| HDL cholesterol | Per 0.4 mmol/l | 1.25 (1.10–1.42) | 0.0007 |
| Triglycerides | Per 0.3 mmol/l | 0.93 (0.88–0.98) | 0.01 |
| logeCRP | Per 0.1 log | 0.99 (0.97–1.02) | 0.87 |
| eGFR | Per 15 ml/min/1.73m2 | 1.16 (1.05–1.29) | 0.003 |
*
OR (95% CI): odds-ratio (95% confidence interval) of having a glutathione peroxidase activity (GPx-3) activity above the median, estimated using age and gender-adjusted logistic regression. eGFR, estimated Glomerular Filtration Rate from MDRD (Modification of the Diet in Renal Disease) formula; logeCRP, logarithmic of high-sensitivity C-Reactive Protein. HT: hypertensive subjects; NT: normotensive subjects.