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. 2013 Jul 26;8(7):e70158. doi: 10.1371/journal.pone.0070158

Figure 2. Cumulative data on hemodynamic findings from sham-operated and pressure-overloaded rats.

Figure 2

A: Valsartan administration improved systolic and diastolic (B) profiles (systolic blood pressure and diastolic blood pressure, SBP and DBP, respectively) in hypertrophied rats. C: Banding of the ascending aorta determined a significant increase in left ventricular maximal pressure (LV max), whereas LV end-diastolic pressure (LVeDP, panel D) was significantly higher in hypertrophic hearts compared to both sham groups and Valsartan-treated hypertrophic hearts. E, F: The maximal and minimal first derivative of the LV pressure over time [LV(dP/dt max) and LV(dP/dt min), respectively] demonstrated improved cardiac function in rats treated with Valsartan for twelve weeks after aortic banding (*p<0.03 vs. all; # p<0.05 vs. SHAM and SHAM+VAL).