Figure 2. Frequency histograms of multifeature scores (MFS_n) for nuclei from various malignant and benign tissue compartments.

Fitted multifeature scores were generated for each nucleus from a logistic regression model comparing all cancer nuclei to normal-far nuclei (>5 mm from a cancer focus) from 20 prostatectomy specimens, with 27 covariate features selected by backwards elimination. Scores were calculated for populations of nuclei obtained from specific histological compartments in 20 RP and 8 cystoprostatectomy specimens. The frequency distributions for normal-far nuclei are significantly different from each other benign type (Kolmogorov-Smirnov D statistic <0.0001).