Table 2. Comparing populations of benign nuclei from negative biopsies in a case-control study: subsequent diagnosis of prostate cancer is associated with a “cancer-like” nuclear morphometric score* (MFSp). Scores derived from external datasets.
Model A* | Model B** | |||
AUC | 95% CI | AUC | 95% CI | |
Case-Control Biopsies: Subsequent PCa vs. No PCa (n = 40 subjects; 20 pairs) | 0.68 | 0.51–0.84 | 0.71 | 0.54–0.87 |
Paired t test P = 0.047 | Paired t test P = 0.026 |
Model A: 5 features selected by backwards elimination (FeretY_ave, MaxDiameter_ave, Elongation_ave, Slope_ave and ODKurtosis_ave).
Model B: 5 features (SumOD_sd, MaxDiam_sd, TSD_sd, TEntropy_sd, No.MedDensityObjects_sd), selected after competition among all models with ≤5 covariates based on leave-one-out AUC.