Table 3. Sample-size estimates based on average basal PD (ENaC)^*.

Treatment Effect (mV)	Total Number of Subjects
	90% Power			80% Power
	Average of Both Nostrils	Most-polarized nostril at Each Visit	Most-polarized nostril at Screening Carried Forward	Average of Both Nostrils	Most-polarized nostril at Each Visit	Most-polarized nostril at Screening Carried Forward
A. Comparison with placebo
−5	154	140	226	116	104	170
−10	40	38	58	32	28	44
−15	20	18	28	16	14	22
−20	12	12	18	10	10	14
−25	10	8	12	8	8	10
B. Within-group comparison **
−5	40	37	58	31	28	44
−10	12	11	16	10	9	13
−15	7	7	9	6	6	7
−20	5	5	6	5	4	5
−25	4	4	5	4	4	4

^*Parts 1 and 2 combined analysis at Day 14.

^**Assume a single-arm study.