Table 4. Sample-size estimates based on delta NPD^*.

Treatment Effect (mV)	Total Number of Subjects
	90% Power			80% Power
	Average of Both Nostrils	Most-polarized nostril at Each Visit	Most-polarized nostril at Screening Carried Forward	Average of Both Nostrils	Most-polarized nostril at Each Visit	Most-polarized nostril at Screening Carried Forward
A. Comparison with placebo
−5	288	206	226	216	154	170
−10	74	54	58	56	42	44
−15	34	26	28	26	20	22
−20	20	16	18	16	12	14
−25	14	12	12	12	10	10
B. Within-group comparison **
−5	73	53	58	56	40	44
−10	26	15	16	16	12	13
−15	11	8	9	9	7	7
−20	7	6	6	8	5	5
−25	6	5	5	5	4	4

^*Parts 1 and 2 combined analysis at Day 14.

^**Assume a single-arm study.