Figure 2. Functional gene categories significantly enriched by HD-HAd, HD-CAV-2 and LV.

Data sets containing the Affymetrix probe identifiers selected as differentially expressed in transduced cells and the corresponding fold changes were uploaded onto IPA. Significant molecular and physiological functions were determined querying the IPA Knowledge Base and selecting a scoring method based on the Fisher's exact test applying the threshold of p-value≤0.01. Significantly enriched IPA categories containing at least 10 genes are listed and the relative score is indicated. Categories were further manually classified into four groups: i) cell cycle and DNA damage, ii) trafficking and neuron remodeling and iii) immune response, iv) other.