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. 2012 Dec 18;154(2):718–726. doi: 10.1210/en.2012-1913

Figure 2.

Figure 2.

PAI-1-H/Kβ mice are hyperphagic and resistant to CCK. A, Increased 24-hour food intake in PAI-1-H/Kβ compared with C57BL/6 mice at 6 to 9, 11 to 14, and 42 to 50 weeks. B, Resistance to the satiating action of ip CCK8s in PAI-1-H/Kβ compared with C57BL/6 mice refed for 30 min after a 24-hour fast (PAI-1-H/Kβ control intake, 0.78 ± 0.06 g/30 min; C57BL/6, 0.53 ± 0.03 g/30 min). C, Administration of ip PAI-1 (2.5 nmol/kg) to C57BL/6 mice stimulates food intake and inhibits the effect of CCK8s (2.5 nmol/kg). D, Reduced weight gain in PAI-1-H/Kβ mice fed the daily food ration consumed by C57BL/6 mice. E, PAI-1-H/Kβ mice pair-fed with C57BL/6 mice (6 weeks), ie, calorie restricted (cal. restrict.) vs control, exhibit hyperphagia and partial sensitivity to CCK8s (2.5 nmol/kg) compared with C57BL/6 mice when subsequently fasted 24 hours and fed for 30 minutes ad libitum. *, P < .05; n = 6–8.