Table 2.
Population studies of DEL
| Population | RHD exons screened | D-negative donors screened | DEL detected | Frequency of DEL among D-negative | Most frequent alleles | Number of different DEL alleles found |
|---|---|---|---|---|---|---|
| Brazil [52] | intron 4, exon 10 | 239 | 0 | <1:80 | ||
| Brazil [48] | intron 4, exon 7, pools of 10 | 2,450 | 19 (including weak D) | 1:129 | ||
| Central Europe [23], | 5’ UTR, 3,10 | 1,700 | 15 DEL + 5 weak D / partial D | 1:113 | RHD(M295I), RHD(IVS3+1G>A) | 3 |
| donors with C or E | ||||||
| China [53] | intron 4, exon 7, (5'UTR, exon 10) | 155 (negative on direct agglutination) | 31 (+3 weak D) | 1:5 | RHD(K409K) | 1 |
| China (Shanghai) [37] | (serologie screening) | 1,585 | 279 | 1:6 | RHD(K409K) | |
| Denmark [9] | 5.7.8 | 5,058 (4,932 results available) | 2* | 1:2,029 | 2 | |
| Denmark [47], | exon 10 | 233 | 3 DEL + 1 weak D | 1:78 | 3 | |
| donors with C or E | ||||||
| Germany(South-West) [8], | 5’ UTR, intron 4, exons 7,10 | 754 | 15 DEL + 4 weak D / partial D | 1:50 | RHD(M295I), RHD(K409K) | 3 |
| donors with C or E | ||||||
| Germany(South-West) [8], | 5'UTR, intron 4, exon 10 | 7,688 | 1 chimeric donor | <1:2,500 | ||
| ccddee donors | ||||||
| Germany (South-West) [28] | intron 4 (pools of 20) | 46,133 | 47 | 1:982 | RHD(IVS3+1G>A), RHD(M295I) | 10 |
| Germany (North) [31, 35] | exon 7 (pools of up to 40) | 46,756 | 76 | 1:615 | RHD(IVS3+1G>A), RHD(M295I) | 15 |
| Italy [54] | commercial PCR systems, pools of 5 | 235 | 1 | 1:235 | RHD(M295I) | 1 |
| Korea [43] | intron 4, exon 7 | 126 | 16 + weak D | 1:8 | RHD(K409K) | 1 |
| Korea [40] | 3.5.7.10 plus intron 4 | 264 | 43 | 1:6 | RHD(K409K) | |
| Upper Austria [39] | 4.7.10 in pools of 20 | 2,427 | 3 | 1:809 | RHD(IVS3+1G>A) | 2 |
| Upper Austria [30] | 4.7.10 in pools of 20 | 23,330 | 66 | 1:353 | weak D type 4.3, RHD(IVS3+1G>A) | 6 |
| Thailand [55] | (serologie screening) | 254 | 50 | 1:5 | RHD(K409K) | |
| Tunisia [56] | 488 | 3 weak D, 1 partial D (missed despite IAT) |
*
In addition, an RHD(IVS3+1G>A) sample was detected but characterized as D-negative.