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. 2013 Jul 9;110(30):12397–12401. doi: 10.1073/pnas.1301918110

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Fig. 3. — Protection by early MAV-1 antisera is dependent upon TRIM21 expression. (A) Survival of T21^+/+ (white circles) and T21^−/− mice (black squares) after infection with 3.6 × 10³ TCID50 of MAV-1. (B) Survival of T21^+/+ (n = 14) and T21^−/− (n = 15) mice upon infection with 3.6 × 10³ TCID50 MAV-1 in the presence of passively transferred early antisera. (C) Survival of T21^+/+ (n = 14) and T21^+/− (n = 16) mice (black triangles) upon infection with 3.6 × 10³ TCID50 MAV-1 in the presence of passively transferred early antisera. (D) Brain viral copies in T21^+/+, T21^+/−, and T21^−/− mice after infection with 3.6 × 10³ TCID50 MAV-1 in the presence of early antisera. (E) Induction of TRIM21 in T21^+/+ (white bar) or T21^+/− (hatched bar) after challenge with 3.6 × 10³ TCID50 MAV-1 and early antisera 7 d postinfection.