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Reduced operant motivation in DN-DISC1 mice. (A and B) DN-DISC1 mice (n = 8) showed a reduction in sucrose intake under progressive ratio test conditions (A) and displayed a corresponding attenuation in the number of licks they were willing to perform during this test relative to controls (n = 7) (B). (C) Dramatic differences in the rate of attrition were revealed between the groups. Main effect of group, *P < 0.05. Error bars indicate SEM.
