Fig. 5.

Three-chamber social interaction test. (A) Sociability: Although wild-type control mice (n = 9) preferred the enclosure with the stranger mouse, DN-DISC1 mice (n = 13) showed no preference. (B) Social novelty: Although control mice preferred the stranger, DN-DISC1 mice preferred the familiar mouse. (C) Social odor detection: There were no differences in initial exploratory activity to the open field as reflected by distance traveled (in centimeters ± SEM) in DN-DISC1 mice (853 ± 67.7, n = 15) and control mice (995 ± 68.4, n = 20). Importantly, both groups of mice showed a preference for the cube containing familiar cage bedding relative to an empty odor cube. *P < 0.05, Group × Chamber interaction.). ^#P < 0.01, odor detection effect. Error bars indicate SEM.