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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: J Clin Periodontol. 2013 Jun 18;40(8):816–824. doi: 10.1111/jcpe.12127

Figure 1. Peri-implant and gingival crevicular fluid biomarkers following implant placement.

Figure 1

IL-8 (A), MIP-1β (B), IL-6 (C), and TIMP-1 (D) total amount/site (mean+SE). Each data point represents crevicular fluid samples (4 strips/site; 20 sec/strip) from 40 patients. Each patient was sampled at peri-implant crevice (I), gingival crevice of adjacent tooth (T+), and gingival crevice of contralateral, non-operated tooth (T-). I and T+ were surgical sites (full-thickness flap elevated to place one-stage dental implant). Week 0 (T+ and T-) refers to immediately pre-operative (baseline) samples. Week 1 values differed significantly from week 12 for IL-8 (I, p=0.0003), MIP1-β (I, p=0.0003), IL-6 (I, p=0.0003; T+, p=0.01), and TIMP-1 (I, p=0.0003; T+, p=0.004). At early healing (weeks 1-3), surgical sites differed significantly from T- sites for IL-8, IL-6, and TIMP-1 (adjusted p≤0.05); as did I from T+ for IL-6 (p≤0.05). At late healing (weeks 6-12), I differed from T+ for MIP1-β (p≤0.03). Additional details provided in text.