Table 5.
Joint effect of HPV16 serology and the combined risk genotypes of TNF-α SNPs on risk of OSCC, stratified by age
|
Risk groups1 |
HPV16 status |
Patients |
Controls |
Adjusted OR (95% CI)2 |
|||
|---|---|---|---|---|---|---|---|
| |
|
(n = 325) |
(n = 335) |
||||
| No. | % | No. | % | OSCC | SCCOP | ||
| Young (aged < 50 years) |
|
(n = 87) |
(n = 87) |
|
|
||
| Low-risk group |
− |
12 |
13.8 |
29 |
33.3 |
1.0 |
1.0 |
| Medium-risk group |
− |
19 |
21.8 |
35 |
40.2 |
1.2 (0.5 − 3.1) |
1.1 (0.3 − 4.5) |
| High-risk group |
− |
24 |
27.6 |
13 |
14.9 |
4.1 (1.5 − 11.5) |
5.5 (1.4 − 21.2) |
| Low-risk group |
+ |
7 |
8.1 |
5 |
5.8 |
4.7 (1.1 − 19.7) |
10.1 (2.0 − 52.3) |
| Medium-risk group |
+ |
9 |
10.3 |
3 |
3.5 |
8.9 (1.8 − 43.5) |
16.6 (2.9 − 6.1) |
| High-risk group |
+ |
16 |
18.4 |
2 |
2.3 |
22.6 (4.2 − 121.3) |
50.7 (7.5 − 341.9) |
| Older (aged ≥ 50 years) |
|
(n = 238) |
(n = 248) |
|
|
||
| Low-risk group |
− |
49 |
20.6 |
52 |
21.0 |
1.0 |
1.0 |
| Medium-risk group |
− |
34 |
14.3 |
94 |
37.9 |
0.4 (0.2 − 0.7) |
0.4 (0.2 − 0.8) |
| High-risk group |
− |
87 |
36.6 |
70 |
28.2 |
1.3 (0.8 − 2.2) |
1.2 (0.6 − 2.3) |
| Low-risk group |
+ |
20 |
8.4 |
8 |
3.2 |
2.5 (1.0 − 6.2) |
3.9 (1.4 − 10.6) |
| Medium-risk group |
+ |
14 |
5.9 |
18 |
7.3 |
0.9 (0.4 − 1.9) |
1.6 (0.6 − 3.9) |
| High-risk group | + | 34 | 14.3 | 6 | 2.4 | 5.7 (2.2 − 15.0) | 10.2 (3.6 − 28.4) |
1Low-risk group: individuals carrying 0–1 risk genotypes; medium-risk group: individuals carrying 2 risk genotypes; and high-risk group: individuals carrying 3 or 4 risk genotypes.
2 Adjusted for age, sex, and smoking and drinking status.