Table 1.
Milk-derived miR | Ref. | miR function in metabolism | Ref. |
---|---|---|---|
miR-21 |
50 |
miR-21: Inhibition of various tumor suppressor gene mRNAs (PTEN, Spouty1, Sprouty2, PDCD4) |
[63-72,75] |
Increased adipogenesis |
[100-102] |
||
miR-29a |
54 |
miR-29a: Down-regulation of Insig-1 with increased lipogenesis and adipocyte differentiation |
[106] |
[107,108] | |||
miR-29b |
51 |
miR-29b: Reduction of BCKD and reduced BCAA catabolism |
[111] |
[110] | |||
miR-103 |
51 |
miR-103: Increased adipogenesis |
[100,105] |
miR-155 |
51 |
miR-155: Reduction of brown adipose tissue and thermogenesis |
[109] |
Let-7a, b, c, f | 51 | Let-7: overexpression results in insulin resistance and disturbed glucose homeostasis | [120,122] |