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. 2013 Jul 25;12:103. doi: 10.1186/1475-2891-12-103

Table 1.

Selected milk-derived miRs and their potential impact on metabolism

Milk-derived miR Ref. miR function in metabolism Ref.
miR-21
50
miR-21: Inhibition of various tumor suppressor gene mRNAs (PTEN, Spouty1, Sprouty2, PDCD4)
[63-72,75]
Increased adipogenesis
[100-102]
miR-29a
54
miR-29a: Down-regulation of Insig-1 with increased lipogenesis and adipocyte differentiation
[106]
[107,108]
miR-29b
51
miR-29b: Reduction of BCKD and reduced BCAA catabolism
[111]
[110]
miR-103
51
miR-103: Increased adipogenesis
[100,105]
miR-155
51
miR-155: Reduction of brown adipose tissue and thermogenesis
[109]
Let-7a, b, c, f 51 Let-7: overexpression results in insulin resistance and disturbed glucose homeostasis [120,122]