Table 2.

Language, neurocognitive test scores and imaging data across clusters. Data shown as median (range); p values calculated using Kruskall-Wallis followed by Mann-Whitney U test for continuous variables and Chi-squared test for categorical variables (ND = Not Done)

	Clusters			P values
	1 “Mild typical lvPPA”	2 “Mild atypical lvPPA”	3 “Severe typical lvPPA”	All	1 vs. 2	1 vs. 3	2 vs. 3
N	9	7	5	-	-	-	-
Gender, female	44%	57%	80%	0.44	ND	ND	ND
Age at onset	65 (54-72)	64 (42-80)	64 (47-70)	0.63	ND	ND	ND
Education	16 (12-20)	15 (12-20)	14 (12-16)	0.26	ND	ND	ND
MMSE	25 (24-29)	26 (15-30)	14 (10-21)	0.005	0.96	0.002	0.007
Disease duration	2.0 (1.0, 3.0)	5.0 (4.0, 6.0)	3.5 (3.0, 5.0)	0.0003	0.0006	0.005	0.02
WAB AQ	83.0 (74.4, 94.4)	86.7 (69.9, 98.8)	55.0 (33.5, 64.8)	0.004	0.92	0.003	0.005
AVLT Del+LM II Z+VRII Z	−1.6 (−2.1, 0.3)	−1.2 (−2.1, 1.7)	−2.3 (−2.5, −2.1)	0.003	0.27	0.003	0.004
TMTB + Sorting Z	−1.3 (−2.9, 0.2)	−1.8 (−3.0, 1.3)	−3.0 (−3.2, −2.7)	0.02	0.67	0.009	0.02
Rey-O +Cube + Inc. Letters Z	−0.2 (−6.1, 0.6)	−0.5 (−6.9, 0.6)	−4.9 (−10.3, −3.3)	0.03	0.71	0.01	0.03
Global Z	−1.1 (−3.6, 0.4)	−1.3 (−3.8, 1.1)	−3.3 (−5.2, −2.8)	0.03	0.71	0.01	0.03
Temporoparietal Z	−2.4 (−3.7, 1.8)	−2.2 (−2.8, 0.3)	−3.2 (−4.1, −3.1)	0.008	0.15	0.03	0.005