. Author manuscript; available in PMC: 2014 Jan 25.
Published in final edited form as: Nature. 2013 Jun 26;499(7459):476–480. doi: 10.1038/nature12276
Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms