Table 2.
Genotype and allele frequencies of PPARγ polymorphisms in controls and women with PCOS
| PPARγ Genotype/Allele | Subjects | χ2 (p) | O.R (95 % C.I) | |
|---|---|---|---|---|
| Controls (n = 300) | PCOS (n = 450) | |||
| Pro12Ala C/G (rs1801282) | ||||
| Genotype | Controls [n (%)] | PCOS [n (%)] | 15.3 (<0.0001) | 0.490 (0.34–0.70) |
| CC | 219 (73.0) | 381 (84.67) | ||
| CG + CG | 81 (27.0) | 69 (15.33) | ||
| Allele | Controls [n (%)] | PCOS [n (%)] | 12.7 (0.0004) | 0.55 (0.39–0.77) |
| C | 517 (86.17) | 827 (91.89) | ||
| G | 83 (13.83) | 73 (8.11) | ||
| His447His C/T (rs3856806) | ||||
| Genotype | Controls [n (%)] | PCOS [n (%)] | 6.24 (0.0125) | 0.66 (0.48–0.92) |
| CC | 198 (66.0) | 335 (74.44) | ||
| CT + TT | 102 (34.0) | 115 (25.56) | ||
| Allele | Controls [n (%)] | PCOS [n (%)] | 5.78 (0.0163) | 0.71(0.53–0.94) |
| C | 492 (82.0) | 779 (86.56) | ||
| T | 108 (18.0) | 121 (13.44) | ||
χ2 test, p < 0.05 is considered significant