Table 4.
Linear regression analysis to find the association of the two PPARγ polymorphisms and their combination with different quantitative phenotypes among controls
| Variable | Pro12Ala p (direction) [95%CI] | His447His p (direction) [95%CI] | Combination p (direction) [95%CI] |
|---|---|---|---|
| BMI (kg/m2) | 0.712 (−) [−0.082, 0.056] | 0.308 (+) [−0.032, 0.01] | 0.702 (+) [−0.031, 0.046] |
| HOMA-IR | 0.536 (−) [−0.210, 0.109] | 0.52 (+) [−0.103, 0.203] | 0.978 (+) [−0.087, 0.090] |
| LH:FSH | 0.837 (+) [−0.139, 0.171] | 0.34 (−) [−0.22, 0.076] | 0.663 (−) [−0.104, 0.07] |
| TT (ng/dl) | 0.893 (−) [−0.165, 0.144] | 0.68 (−) [−0.18, 0.117] | 0.755 (−) [−0.099, 0.072] |
| LDL (mg/dl) | 0.185 (−) [−0.190, 0.037] | 0.606 (−) [−0.138, 0.081] | 0.302 (−) [−0.096, 0.03] |
| HDL-C (mg/dl) | 0.169 (+) [−0.04, 0.224] | 0.312 (−) [−0.192, 0.062] | 0.86 (+) [−0.067, 0.08] |
| Fasting Insulin (μIU/ml) | 0.402 (−) [−0.224, 0.09] | 0.601 (+) [−0.111, 0.191] | 0.871 (−) [−0.095, 0.080] |
| QUICKI | 0.541 (+) [−0.017, 0.032] | 0.492 (−) [−0.031, 0.015] | 0.954 (−) [−0.014, 0.013] |
| 2 h glucose (mg/dl) | 0.545 (−) [−0.075, 0.034] | 0.539 (+) [−0.038, 0.072] | 0.985 (+) [−0.032, 0.032] |
The p-value for testing the significance of the beta coefficients along with their directions are given in the table. The directions of the beta coeffecients as well as the 95 % C.I are given in parenthesis. t-test was used to test the siginificance of the beta coefficient. p < 0.05 is considered significant