. Author manuscript; available in PMC: 2013 Jul 28.

Published in final edited form as: J Crit Care. 2009 Aug 13;24(4):568–574. doi: 10.1016/j.jcrc.2009.05.015

Table 2.

Dosing and hemodynamic findings

	Protocol (n = 25)	Historical control (n = 19)	P
Loading infusion administered (%)	0	7.7	.19
Initial dosage (μg kg⁻¹ h⁻¹)	0.24 ± 0.08	0.22 ± 0.07	.42
Maximum dosage (μg kg⁻¹ h⁻¹)	0.43 ± 0.02	0.54 ± 0.16	.08
Mean shortest time between titration (min)	110.8 ± 173.6	12.8 ± 6.6	.02
Median length of infusion (h)	19.2	16.6	.14
No. of dosing changes	4.8 ± 3.8	7.8 ± 3.9	.014
Mean time to maximum dosage (h)	4.8 ± 7.5	2.03 ± 2.51	.14
Hypotension (%)	16	68.4	.0006
Bradycardia (%)	20	15.4	>.99
Mean time to adverse effect (h)	7.9 ± 7.7	3.8 ± 3	.18
Nadir mean arterial pressure (mm Hg)	51.8 ± 2.2	51.1 ± 7.6	.87

Continuous data presented as mean ± standard deviation.