Table 4.

Comparison of hypotension and bradycardia associated with dexmedetomidine in comparative studies

Reference (y)	Study characteristics	Hypotension	Blood pressure (mm Hg)	Bradycardia	Heart rate (beats/min)
Corbett et al (2005) [20]	DEX n = 43 Propofol n = 46	Not reported	Lowest SBP 79.1 ± 12.8 83.2 ± 10 P = .096	Not reported	Lowest 68.1 ±10.1 74.9 ± 11.2 P = .003
Elbardie et al (2004) [15]	DEX n = 30 Propofol n = 30	Not reported	Not reported	Not reported	Mean HR at 8 h 75 88 P = .041
Herr et al (2003) [18]	DEX n = 148 Propofol n = 147	26% 16% P = .11		3% 1% P = .44	Similar
Pandharipande et al (2007) [17]	DEX n = 52 Lorazepam n = 51	SBP <80 mm Hg 25% 20% P =0.51		17% 4% P = .03
Riker et al (2009) [22]	DEX n = 244 Midazolam n = 122	SBP <80, DBP <50 or 30% ↓ 56.1% 55.7% P = .99		HR <40 or 30% ↓ 42.2% 18.9% P < .001
Venn and Grounds (2001) [19]	DEX n = 20 Propofol n = 20	Not reported	Similar	Not reported	Mean HR 75 90 P = .0034
Venn et al (1999) [16]	DEX n = 66 Placebo n = 51	23% Not reported	During first hour SBP and DBP significant lower in DEX group	15% Not reported	Significant lower heart rate during infusion in DEX group

DBP indicates diastolic blood pressure; DEX, dexmedetomidine; HR, heart rate; SBP, systolic blood pressure.