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. Author manuscript; available in PMC: 2013 Dec 27.
Published in final edited form as: Nature. 2013 Jun 5;498(7455):521–525. doi: 10.1038/nature12283

Figure 4. A model for amantadine or rimantadine inhibition of the p7 channel.

Figure 4

The two-dimensional cartoon drawing mimics the sectional view of the p7 channel in Fig. 2b. The channel undergoes conformational switching between the closed and the open states but favors the open state in the presence of cations (blue circles). Binding of amantadine or rimantadine (green circle) favors the closed state by restricting movements of the three helical segments that may be required for channel opening.