Table 3.
Assessment sheet
| Section | Anatomical region | Vacuolation size: S,M,C* | Kuru type plaques yes/no | Florid type plaques yes/no | PrP synaptic yes/no | PrP coarse/ peri vacuolar yes/no | PrP plaque-like yes/no | PrP perineuronal yes/no | Comments |
|---|---|---|---|---|---|---|---|---|---|
| 1. Cerebellum (Cbl) | molecular cell layer | ** | |||||||
| granular cell layer | |||||||||
| white matter | |||||||||
| 2. Frontal Cortex (FCtx) | |||||||||
| 3. Occipital Cortex (OCtx) | |||||||||
| 4. Hippocampus (Hipp) | CA4 | ||||||||
| CA1/subiculum | |||||||||
| 5. Striatum (Str) | caudate/putamen |
*
S=small vacuoles, M=medium size vacuoles, C=Clusters of large confluent vacuoles. It can be either one or more (S or S+M or S+C and so on…)
**
Grey boxes are not required to be filled in.
| 1) Is there a clear-cut laminar pattern in the cerebral cortex (deep cortical layers more affected by spongiform change/PrP-deposits than the superficial ones)? (YES/NO): | __________ |
| 2) Is there a significant relative sparing of the hippocampus compared to the occipital cortex? (YES/NO): | __________ |
| 3) Is there a significant relative sparing of the cerebellum compared to the frontal cortex? (YES/NO): | __________ |
| 4) Is there a moderate to severe atrophy of the medial thalamic nuclei without spongiform change? (YES/NO): | __________ |
| 5) Is there a moderate to severe atrophy of the inferior olivary nuclei? (YES/NO): | __________ |
| Classification of CJD type (tick one box): |
|
| COMMENTS: _______________ | |