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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Brain Behav Immun. 2012 Jun 9;26(7):1047–1056. doi: 10.1016/j.bbi.2012.06.002

Fig. 2.

Fig. 2

HPA system parameter differences in patient subgroups versus matched healthy controls. **p≤ .01, *p≤ .05, †p≤ .10. Paired t-test comparisons of patients and individually-matched healthy controls on systems-derived neuroendocrine outcomes. Fatigue-predominant patients (n = 14) met criteria for CFS and not FM, whereas pain-predominant patients (n = 22) met criteria for FM with or without chronic fatigue. These subtypes are associated with significant differences in neuroendocrine system activity. The y-axis represents the mean differences (from case-control paired t-tests) of two system parameters (ACTH-adrenal signaling and inhibitory cortisol feedback signaling). Positive values indicate that patients exhibited amplified signaling relative to controls, whereas negative values indicate decreased signaling of patients relative to controls.