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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Radiat Res. 2013 Apr 26;179(6):617–629. doi: 10.1667/RR3279.1

FIG. 4.

FIG. 4

Clara cell secretory protein (CCSP) mRNA and CCSP protein expression in airway epithelial cells after infection in sham and irradiated mice. At 10 weeks post-irradiation, sham and 15 Gy whole-lung irradiated mice were infected with 120 HAU influenza A virus. CCSP was used as a marker for airway epithelial Clara cells. Panel A: CCSP mRNA abundance in the lungs at 9, 14 and 21 days post-infection. Abundance is expressed as fold change over GAPDH internal control. (Two-way ANOVA with Fisher’s post-test, *P < 0.05 versus sham-infected, n =3–6 per group.) Panel B: Representative images (10×) of CCSP-expressing cells (red) in mock-infected animals and at day 21 post-infection. Panel C: Percentage of airway staining positive for CCSP in mock-infected or virus-infected sham and irradiated groups. Two-way ANOVA with Fisher’s post-test, *P < 0.05 versus sham-infected, n = 3–6 per group.