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. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: Clin Pharmacol Ther. 2012 Sep 5;92(5):599–612. doi: 10.1038/clpt.2012.79

Figure 3. Schematic representation of Dubin-Johnson-Syndrome.

Figure 3

Left panel: Under normal conditions, MRP2 excretes bilirubin-glucuronide into bile. Right panel: Loss-of-function of MRP2 results in accumulation of bilirubin-glucuronide in the hepatocyte. Increased MRP3 on the basolateral membrane of the hepatocytes transports bilirubin-glucuronide into the sinusoidal blood, resulting in conjugated hyperbilirubinemia in the systemic circulation. The broken lines represent minimal or no transport.