Table 1.
Selected References to Studies Supporting the Integration of D2-Like Receptor Signaling with GLP-1 Receptor Signaling.
| Possible Phosphor-proteome Sites of Integration of D2-Like Receptor Signaling into β-Cell Signaling | References to β-Cell/GLP-1 Receptor Signaling | References to D2-Like Receptor Signaling |
|---|---|---|
| AKT/PKB /p-AKT Ser 473, Thr 308 | (89, 105) | (90, 91, 106) |
| GSK-3/p-GSK-3 (Ser 9, Ser 21, Thr-390) | (107, 108) | (91, 109–111) |
| 14–3–3 / p-14–3–3 | (112) | (112) |
| p70 S6 Kinase / p-p70 S6K | (113) | (106) |
| PKCζ/p-PKC (Thr410) | (114, 115) | (116, 117) |
| ERK/p-ERK 1/2 (Thr202/Tyr204) | (118) | (119) |
| CaMKII/p-CaMKII (Tyr231 or 286) | (120, 121) | (120–122) |
| DARPP-32/p-DARPP-32 (Thr 34 75) | (123, 124) | (106, 125) |
| CREB/ p-CREB (Ser133) | (126) | (119) |
| CDK5/ p-CDK5 | (124) | (125) |
| Rap1/p-Rap1 | (127) | (128) |
| Munc18/ p-Munc18 | (129) | (130) |
AKT/PKB, protein kinase B; CaMK, calmodulin-dependent kinase; CDK, cyclin-dependent kinase; CREB, cAMP response element binding protein; DARPP, dopamine- and cAMP-regulated phospho-protein; GSK, glycogen synthase kinase; p-ERK, phospho-ERK; pGSK, phospho-GSK; p-PKC, phospho-protein kinase C.