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. 2013 Jun 27;27(8):1267–1282. doi: 10.1210/me.2013-1029

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Copyright © 2013 by The Endocrine Society

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Figure 4. — Molecular analysis of human GPR119 (hGPR119) signal transduction in GLUTag cells. (A, B) The constitutive action of human GPR119 to activate −2400 Glu-Luc was dose-dependently blocked when GLUTag cells were transfected with a DN G_αs protein (A) or a DN PKA regulatory subunit (DN PKAR) (B). C, −2400 Glu-Luc was activated in GLUTag cells transfected with a PKA catalytic subunit (PKA_cat). D, the constitutive action of human GPR119 at −2400 Glu-Luc was blocked in GLUTag cells transfected with a DN A-CREB.