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. 2013 Jul 28;19(28):4486–4494. doi: 10.3748/wjg.v19.i28.4486

Figure 4.

Figure 4

Effect of Delta-like ligand 4 up-regulation on the secretion and activation of extracellular matrix metalloproteinases. Twenty microlitres of culture supernatant from each group was used. Coomassie Blue R-250 staining of the zymogram revealed significantly increased matrix metalloproteinases (MMP)-2 proenzyme but decreased MMP-9 proenzyme in the SGC7901-Delta-like ligand 4 (DLL4) group vs the SGC7901-vector group. SGC7901-vector: SGC7901 cells transfected with an empty vector; SGC7901-DLL4: SGC7901 cells transfected with vector encoding human DLL4 gene; Control: Non-transfected SGC7901 cells.