Table 1.
Clinical data from cross-sectional study (A) are displayed as median (interquartile range); the longitudinal pilot study (B) data shows individual clinical parameters and neuropsychological scores from outside scanner acquired on and off TPM.
| (A) Cross-sectional data | |||
|---|---|---|---|
| Controls (24) | TPM (8) | Other AEDS (27) | |
| Age (years) | 30 (7) | 30 (13) | 35 (20) |
| Gender (f/m) | 13/11 | 4/4 | 11/16 |
| NART-IQ | 111 (10.5) | 96 (12) | 97 (14) |
| Letter fluency “S” | 15.5 (7) | 9 (8) | 10 (4) |
| Categorical fluency | 23.5 (4) | 17 (10) | 18 (9) |
| Age of onset | – | 7.5 (3) | 9 (6) |
| Duration (years) | – | 24.5 (14) | 21 (16) |
| Seizure frequency (partial/month) | – | 15 (25.5) | 20 (116) |
| Specific AED dose (mg/day) | – | 187.5 (175) | – |
| Polytherapy (%) | – | 100% | 100% |
| Number of AEDs | – | 3 (1.5) | 3 (1) |
| (B) Longitudinal pilot study | ||||||
|---|---|---|---|---|---|---|
| Subject 1 | Subject 2 | Subject 3 | Subject 4 | Subject 5 | Subject 6 | |
| Age | 35 | 23 | 22 | 40 | 28 | 56 |
| Age of onset (years) | 6 | 4 | 21 | 9 | – | – |
| Duration (years) | 29 | 19 | 1 | 31 | – | – |
| Classification | FLE | Occipital Tuberous |
FLE | TLE Temporal |
Control | Control |
| MRI | Normal | Sclerosis | Normal | Resection | Control | Control |
| Type of intervention | ON–OFF | ON–OFF | OFF–ON | OFF–ON | Acute | Acute |
| TPM dose (mg) | 200 | 300 | 150 | 325 | 200 | 200 |
| Serum levels (μmol/L) | ||||||
| Range 6–74 | – | – | – | – | 8 | 0.48 |
| On | Off | On | Off | On | Off | On | Off | On | Off | On | Off | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Letter fluency | 8 | 16 | 12 | 22 | 19 | 14 | 3 | 11 | 23 | 37 | 22 | 22 |
| Categorical fluency | 10 | 13 | 16 | 31 | 26 | 35 | 9 | 11 | 13 | 45 | 16 | 22 |
| Digit backwards | – | 7 | 2 | 4 | 4 | 7 | 4 | 5 | 11 | 14 | 9 | 7 |
| Other AEDs (number) | 3 | 3 | 2 | 2 | – | – | 2 | 3 | – | – | – | – |