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. 2013 Jul 29;4:219. doi: 10.3389/fimmu.2013.00219

Figure 4.

Figure 4

Partial deletion of arginase 1 (ARG1+/−) prevents DOCA-salt-induced endothelial dysfunction in aorta and mesenteric artery (MA). Concentration-response curves to acetylcholine (ACh, 0.001–10 μM) in aorta (A,B) and MA (C,D) from WT, ARG1+/−, or ARG2−/− mice in uninephrectomized (WT Sham) or DOCA-salt treated mice. Data were calculated relative to the maximal changes from the contraction produced by phenylephrine (PE, 1 μM), which was taken as 100%. Data are means ± SEM of six to eight experiments. *P < 0.05, indicates differences in pEC50 values of the dose-response curves. #P < 0.05, compared with WT Sham group.