Figure 5.

Inhibition of arginase ameliorates DOCA-salt-induced endothelial dysfunction. Treatment with an inhibitor of arginase (ABH, 100 μM; 60 min) prevented vascular endothelial dysfunction in DOCA-salt treated mice in aorta (A) and mesenteric artery [MA; (C)]. WT Sham vessels exposed to ABH showed no change in the ACh-induced vasorelaxation in aorta (B) and MA (D). Data were calculated relative to the maximal changes in contraction produced by phenylephrine (PE, 1 μM), which was taken as 100%. Data are means ± SEM of four experiments. *P < 0.05, compared with WT-DOCA + ABH group.